听力与言语-语言病理学

行为科学

医学伦理学

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  • Prognostic significance of vascular endothelial growth factor D in gastric carcinoma.

    abstract::The angiogenic factor called vascular endothelial growth factor (VEGF)-D is a ligand for VEGF receptor-2 (VEGFR-2/KDR) and receptor-3 (VEGFR-3/Flt-4). It is implicated in the development of lymphatic vessels and promotion of lymphatic metastasis. The purpose of this study was to investigate the prognostic significance...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-0076-z

    authors: Shida A,Fujioka S,Ishibashi Y,Kobayashi K,Nimura H,Mitsumori N,Suzuki Y,Kawakami M,Urashima M,Yanaga K

    更新日期:2005-12-01 00:00:00

  • Laparoscopy-assisted gastrectomy for early gastric cancer in young and elderly patients.

    abstract::Open gastric surgery in elderly patients is associated with higher morbidity and mortality rates than those reported among younger individuals. Therefore, minimally invasive surgery may have a larger impact on the elderly compared to the younger age group. The objective of this study was to evaluate the experience of ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-0208-5

    authors: Mochiki E,Ohno T,Kamiyama Y,Aihara R,Nakabayashi T,Asao T,Kuwano H

    更新日期:2005-12-01 00:00:00

  • Mirizzi syndrome: ten years experience from a teaching hospital in Riyadh.

    abstract:OBJECTIVE:Mirizzi syndrome (MS) is an uncommon presentation of cholelithiasis. This study aims to find the incidence and analyze the outcome of management of this condition at Riyadh Medical Complex (RMC) with particular reference to diagnostic methods and outcome of surgical treatment. METHODS:Retrospective study on ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-0100-3

    authors: Al-Akeely MH,Alam MK,Bismar HA,Khalid K,Al-Teimi I,Al-Dossary NF

    更新日期:2005-12-01 00:00:00

  • Access to care and satisfaction in colorectal cancer patients.

    abstract::This study described the various components of access to care for resectable colorectal cancer, and correlated the timeliness of these components with patient satisfaction. With a prospective/retrospective cohort design, all patients undergoing surgical resection for primary colorectal cancer from 2/1/01 to 15/12/01, ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7955-1

    authors: Porter GA,Inglis KM,Wood LA,Veugelers PJ

    更新日期:2005-11-01 00:00:00

  • Clinical and radiologic evaluation of foramen of Morgagni hernias and the transthoracic approach.

    abstract::The limited number of publications on repair of the foramen of Morgagni hernia concentrates mainly on the laparotomy approach. We present our experience with the transthoracic approach. Patients who were diagnosed as having a foramen of Morgagni hernia and were operated on via the transthoracic approach between Decemb...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-0055-4

    authors: Sirmali M,Türüt H,Gezer S,Findik G,Kaya S,Tastepe Y,Cetin G

    更新日期:2005-11-01 00:00:00

  • A new knot technique for vessel ligatures.

    abstract::A new technique for ligating vessels and similar structures that offers more security is described. The aim of the study was to test whether this hypothesis was correct. Six different types of knots, including the one described in this article were compared by a strength-testing study. The knots were tied on a silicon...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-005-7675-6

    authors: Botet X,Surinyach S,Molinas J

    更新日期:2005-10-01 00:00:00

  • The volume-outcome relationship: don't believe everything you see.

    abstract::This paper investigates methodological limitations of the volume-outcome relationship. A brief overview of quality measurement is followed by a discussion of two important aspects of the relationship. ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-005-7993-8

    authors: Christian CK,Gustafson ML,Betensky RA,Daley J,Zinner MJ

    更新日期:2005-10-01 00:00:00

  • Effect of oral glutamine administration on bacterial tanslocation, endotoxemia, liver and ileal morphology, and apoptosis in rats with obstructive jaundice.

    abstract::Postoperative complications in patients with obstructive jaundice remain increased when associated with endotoxemia and the inflammatory response due to gut barrier failure. Administration of glutamine has been proposed to maintain the integrity of the gut mucosa and thus reduce bacterial translocation (BT), but the e...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7721-4

    authors: Margaritis VG,Filos KS,Michalaki MA,Scopa CD,Spiliopoulou I,Nikolopoulou VN,Vagianos CE

    更新日期:2005-10-01 00:00:00

  • Omental flap in pancreaticoduodenectomy for protection of splanchnic vessels.

    abstract::Intraabdominal bleeding, the most life-threatening complication following pancreaticoduodenectomy (PD), most often is associated with failure of a pancreaticojejunostomy anastomosis or with intraabdominal infection. We investigated whether placement of an omental flap around the splanchnic vessels in PD could reduce t...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7900-3

    authors: Maeda A,Ebata T,Kanemoto H,Matsunaga K,Bando E,Yamaguchi S,Uesaka K

    更新日期:2005-09-01 00:00:00

  • Long-term survival of patients with gallbladder cancer detected during or after laparoscopic cholecystectomy.

    abstract::Little evidence is available regarding long-term survival of patients with gallbladder cancer that is discovered at the time of laparoscopic cholecystectomy (LC). Therefore the present study was performed to evaluate long-term outcomes of this disease. Of 1546 patients who underwent LC for benign gallbladder disease b...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7886-x

    authors: Akatsu T,Ueda M,Shimazu M,Wakabayashi G,Aiura K,Tanabe M,Kawachi S,Kido H,Kitajima M

    更新日期:2005-09-01 00:00:00

  • A new approach to accurate diagnosis of acute appendicitis.

    abstract::This study aimed (1) to develop a simple scoring system incorporating ultrasound (US) examination and clinical or laboratory predictors for increasing diagnostic accuracy in acute appendicitis (AA), and (2) to evaluate the performance of the scoring system as compared to that of previous models. Fifteen variables incl...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7853-6

    authors: Tzanakis NE,Efstathiou SP,Danulidis K,Rallis GE,Tsioulos DI,Chatzivasiliou A,Peros G,Nikiteas NI

    更新日期:2005-09-01 00:00:00

  • Long-term efficacy of distal splenorenal shunt with splenopancreatic and gastric disconnection for esophagogastric varices in patients with idiopathic portal hypertension.

    abstract::Idiopathic portal hypertension (IPH) requires invasive measures to prevent rupture and bleeding of esophagogastric varices. However, the long-term results of shunt surgery for IPH have not been reported. In particular, the pros and cons of surgery that preserves the spleen and its long-term hematologic effects have no...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7656-9

    authors: Hase R,Hirano S,Kondo S,Okushiba S,Morikawa T,Katoh H

    更新日期:2005-08-01 00:00:00

  • Groin hernia repair: postherniorrhaphy pain.

    abstract::Persistent pain after hernia repair is common, although it is usually mild. In 3% of patients it is severe, however, and has significant effects on work and social activities. The purpose of this review was to examine factors that affect pain after hernia repair. Although the type of anaesthetic used, local or general...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-005-7903-0

    authors: O'Dwyer PJ,Alani A,McConnachie A

    更新日期:2005-08-01 00:00:00

  • Incisional hernia repair: abdominoplasty, tissue expansion, and methods of augmentation.

    abstract::Incisional hernia repair without mesh mainly consists of tissue transfer to bridge or close the defect. Bridging includes rotational or free musculocutaneous flaps, rendering acceptable short-term results but a rather disappointing long-term outcome. Abdominal wall closure where there has been significant loss of doma...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-005-7972-0

    authors: Van Geffen HJ,Simmermacher RK

    更新日期:2005-08-01 00:00:00

  • Influence of surgery-related factors on quality of life after esophageal or cardia cancer resection.

    abstract::Knowledge of how factors related to esophageal cancer resection affect long-term quality of life after surgery is scarce, and no population-based studies are available. Therefore, we conducted a Swedish nationwide, prospective, population-based study of how esophageal surgery-related factors influence quality of life ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7887-9

    authors: Viklund P,Lindblad M,Lagergren J

    更新日期:2005-07-01 00:00:00

  • Comparison of surgical techniques for treatment of benign toxic multinodular goiter.

    abstract::Controversy remains regarding the best surgical approach for toxic multinodular goiter (MNG). The aim of this study was to evaluate the results of various thyroid operations for managing toxic MNG. A group of 100 patients with toxic MNG were divided into three groups and managed with total thyroidectomy (TT; group I, ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7767-3

    authors: Alimoglu O,Akdag M,Sahin M,Korkut C,Okan I,Kurtulmus N

    更新日期:2005-07-01 00:00:00

  • Complications with reconstruction procedures in pylorus-preserving pancreaticoduodenectomy.

    abstract::This study was conducted retrospectively to examine the efficacy of Traverso reconstruction compared with Billroth I reconstruction after pylorus-preserving pancreaticoduodenectomy, in the prevention of several complications. Pylorus-preserving pancreaticoduodenectomy is an aggressive surgery, and insufficiency of the...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7697-0

    authors: Tani M,Kawai M,Terasawa H,Ueno M,Hama T,Hirono S,Ina S,Uchiyama K,Yamaue H

    更新日期:2005-07-01 00:00:00

  • Effect of radiofrequency ablation of the liver on cell-mediated immunity in rats.

    abstract::We investigated the effect of radiofrequency ablation (RFA) of the liver on cell-mediated immunity in rats. Sprague-Dawley rats were divided into five groups: control group that did not have any procedure, a sham-operation group that underwent laparotomy, a lobectomy group that had left lateral lobectomy of the liver,...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7728-x

    authors: Yu HC,Moon JI,Jin ZW,Lee DY,Kim CY,Song CH,Cho BH

    更新日期:2005-06-01 00:00:00

  • Number needed to treat (or harm).

    abstract::The effect of a treatment versus controls may be expressed in relative or absolute terms. For rational decision-making, absolute measures are more meaningful. The number needed to treat, the reciprocal of the absolute risk reduction, is a powerful estimate of the effect of a treatment. It is particularly useful becaus...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7916-8

    authors: Tramèr MR,Walder B

    更新日期:2005-05-01 00:00:00

  • Hemodynamic and respiratory effects of robot-assisted laparoscopic fundoplication in children.

    abstract::Laparoscopic fundoplication is increasingly used for treating gastro-esophageal reflux disease in children. Mechanical and pharmacological effects may contribute to hemodynamic and respiratory changes during carbon dioxide pneumoperitoneum. The aim of the present study was to evaluate the hemodynamic and respiratory e...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-005-7695-2

    authors: Meininger D,Byhahn C,Mierdl S,Lehnert M,Heller K,Zwissler B,Bremerich DH

    更新日期:2005-05-01 00:00:00

  • Dropped gallstones during laparoscopic cholecystectomy: the consequences.

    abstract::During laparoscopic cholecystectomy, gallbladder perforation has been reported, leading to bile leak and spillage of gallstones into the peritoneum. Because the consequences can be dangerous, conversion to laparotomy as an instant management for gallstone spillage is one of the topics of current discussion in laparosc...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7588-9

    authors: Tumer AR,Yüksek YN,Yasti AC,Gözalan U,Kama NA

    更新日期:2005-04-01 00:00:00

  • Searching for non-RET molecular alterations in medullary thyroid carcinoma: expression analysis by mRNA differential display.

    abstract::Some 25%-70% of sporadic medullary thyroid carcinomas (MTCs) are associated with somatic mutations within the RET proto-oncogene. In a significant number of MTCs, however, no such genetic variations can be detected, which implies alternative pathogenic molecular alterations. To assess altered RET mutation-specific gen...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7748-y

    authors: Musholt TJ,Hanack J,Brehm C,von Wasielewski R,Musholt PB

    更新日期:2005-04-01 00:00:00

  • Pancreatoduodenectomy for tumors of Vater's ampulla: report on 94 consecutive patients.

    abstract::Evaluation of prognostic factors of adenocarcinoma of Vater's ampulla is still a matter of debate. The aim of this study was to evaluate retrospectively factors that influence early and long-term outcomes in a 20-year single-institution experience on ampullary carcinoma. A total of 94 consecutive patients with ampulla...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7498-x

    authors: Di Giorgio A,Alfieri S,Rotondi F,Prete F,Di Miceli D,Ridolfini MP,Rosa F,Covino M,Doglietto GB

    更新日期:2005-04-01 00:00:00

  • Roles of cyclophilins in cancers and other organ systems.

    abstract::Cyclophilins are originally identified as cellular binding proteins for the immunosuppressive drug cyclosporin A. Many cyclophilins, including CypA, CypB, CypC, CypD, and Cyp40, have been discovered and shown to be ubiquitously distributed in many types of cells and organ systems. Recent investigations have uncovered ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-004-7812-7

    authors: Yao Q,Li M,Yang H,Chai H,Fisher W,Chen C

    更新日期:2005-03-01 00:00:00

  • Bacterial translocation: not a clinically relevant phenomenon in colorectal cancer.

    abstract::The aim of this study was to identify the risk factors for bacterial translocation and to determine the clinical significance of bacterial translocation in patients with colorectal cancer. Mesenteric lymph node sampling was performed to identify the presence of bacterial translocation in 75 patients with colorectal ca...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7576-0

    authors: Takesue Y,Kakehashi M,Ohge H,Uemura K,Imamura Y,Murakami Y,Sasaki M,Morifuji M,Yokoyama Y,Kouyama M,Okii K,Sueda T

    更新日期:2005-02-01 00:00:00

  • Occult intrabiliary rupture of hydatid cysts in the liver.

    abstract::The aim of this study was to investigate the effects of various surgical modalities directed at the cavity of hydatid cysts in patients with occult intrabiliary rupture. In this respect, 324 patients with hydatid cyst of the liver operated on during 1983-2003 were analyzed; among them, 39 patients with occult intrabil...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7571-5

    authors: Hamamci EO,Besim H,Sonisik M,Korkmaz A

    更新日期:2005-02-01 00:00:00

  • Cardiopulmonary assessment: is improvement needed?

    abstract::Clinical parameters alone have repeatedly been proven unreliable in assessing cardiopulmonary status, especially in hemodynamically unstable patients. To learn if we had a diagnostic problem in our hospital, we compared physician assessment of cardiac index (CI) and thoracic fluid content (TFC) to values obtained usin...

    journal_title:World journal of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00268-004-2073-z

    authors: Van De Water JM,Dalton ML,Parish DC,Vogel RL,Beatty JC,Adeniyi SO

    更新日期:2005-01-01 00:00:00

  • Wound healing enhancement: electroporation to address a classic problem of military medicine.

    abstract::The major goal of wound healing biology is to determine how a wound can be induced to repair damaged tissue faster and more efficiently. Enhancement of dermal and epidermal regeneration is an extremely important goal for the treatment of many different types of wounds. Exogenous application of growth factors to the wo...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-004-2062-2

    authors: Ferguson M,Byrnes C,Sun L,Marti G,Bonde P,Duncan M,Harmon JW

    更新日期:2005-01-01 00:00:00

  • Role of ganglion cells in sigmoid volvulus.

    abstract::The aim of this study was to clarify the role of ganglion cells in the development and recurrence of sigmoid volvulus. We analyzed 9 samples obtained from 9 patients who had undergone sigmoidectomy for sigmoid volvulus, and, for comparison, 18 samples from 18 patients who had undergone sigmoidectomy or low anterior re...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7462-9

    authors: Furuya Y,Yasuhara H,Yanagie H,Naka S,Takenoue T,Shinkawa H,Niwa H,Kikuchi T,Nagao T

    更新日期:2005-01-01 00:00:00

  • Intraoperative parathyroid hormone monitoring.

    abstract::The principles of minimally invasive parathyroidectomy include the successful preoperative localization of a solitary adenoma, a targeted operative approach that does not disturb the normal parathyroid glands, and intraoperative confirmation of excision of all hypersecreting parathyroid tissue. By providing real-time ...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-004-7641-8

    authors: Inabnet WB

    更新日期:2004-12-01 00:00:00

  • Current strategies for surgical management and adjuvant treatment of childhood papillary thyroid carcinoma.

    abstract::Childhood papillary thyroid carcinoma is associated with more locally aggressive and more frequent distant disease than its adult counterpart. Recurrence rates tend to be higher in children, but cause-specific mortality remains low. Optimal initial treatment of childhood papillary thyroid carcinoma should include tota...

    journal_title:World journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1007/s00268-004-7605-z

    authors: Thompson GB,Hay ID

    更新日期:2004-12-01 00:00:00

  • Detection of asymptomatic differentiated thyroid carcinoma by neck ultrasonographic screening for familial nonmedullary thyroid carcinoma.

    abstract::Mass screening for the purpose of detecting thyroid cancer at its earliest stage may not be recommended at the present time, but screening focused on certain risk groups is advocated. Familial nonmedullary thyroid carcinoma (FNMTC) is a distinct clinical entity with a high incidence of multifocality and association wi...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7676-x

    authors: Uchino S,Noguchi S,Yamashita H,Murakami T,Watanabe S,Ogawa T,Tsuno A,Shuto S

    更新日期:2004-11-01 00:00:00

  • 131I-meta-iodobenzylguanidine in the management of metastatic midgut carcinoid tumors.

    abstract::The management of metastatic neuroendocrine tumors incorporates multimodal therapy with surgery, biotherapy, and chemotherapy. Tumor-targeted therapies using radiolabeled octreotide and metaiodobenzylguanidine (mIBG) represent a novel treatment approach. The aim of this study was to evaluate the effectiveness of 131I-...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7603-1

    authors: Sywak MS,Pasieka JL,McEwan A,Kline G,Rorstad O

    更新日期:2004-11-01 00:00:00

  • Optimizing the treatment of AMES high-risk papillary thyroid carcinoma.

    abstract::A minority of patients with papillary thyroid carcinoma (PTC) is at high-risk of developing recurrent disease and death. Risk group stratification as defined by age, metastases to distant site, extrathyroidal invasion, and tumor size (AMES) criteria is frequently employed to identify high-risk patients for aggressive ...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7420-6

    authors: Lo CY,Chan WF,Lam KY,Wan KY

    更新日期:2004-11-01 00:00:00

  • Serum hyaluronate level for predicting subclinical liver dysfunction after hepatectomy.

    abstract::The serum hyaluronate (HA) level reflects sinusoidal endothelial cell function correlated with liver function. We have reviewed multiple liver function indicators from 37 patients who underwent hepatectomy for various liver diseases. The serum HA level was well correlated with the indocyanine green retention rate at 1...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7389-1

    authors: Mizuguchi T,Katsuramaki T,Nobuoka T,Kawamoto M,Oshima H,Kawasaki H,Kikuchi H,Shibata C,Hirata K

    更新日期:2004-10-01 00:00:00

  • Improved health-related quality of life after coronary artery bypass grafting is unrelated to use of cardiopulmonary bypass.

    abstract::This prospective study was instituted to assess whether the use of the on-pump method or the off-pump method affects changes in health-related quality of life (QOL) as evaluated a year after coronary artery bypass graft (CABG) surgery. Data including preoperative risk factors and postoperative morbidity up to discharg...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7486-1

    authors: Järvinen O,Saarinen T,Julkunen J,Laurikka J,Huhtala H,Tarkka MR

    更新日期:2004-10-01 00:00:00

  • Gasless video-assisted total thyroidectomy in the treatment of low risk intrathyroid papillary carcinoma.

    abstract::Video-assisted thyroidectomy, although an increasingly used method to treat benign thyroid nodules, is rarely used to treat thyroid cancer. We performed gasless video-assisted total thyroidectomy for the treatment of papillary carcinoma of the thyroid. The patients were two men and five women with ages ranging from 29...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7446-9

    authors: Chao TC,Lin JD,Chen MF

    更新日期:2004-09-01 00:00:00

  • Value of fentanyl in flexible sigmoidoscopy.

    abstract::Studies have recorded significant patient discomfort during flexible sigmoidoscopy when it is performed without sedation/analgesia. This study observed whether a single dose of 50 mcg intravenous fentanyl reduces pain, improving compliance, acceptability, and completion rates. In a prospective study, 109 consecutive p...

    journal_title:World journal of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00268-004-7374-8

    authors: Basu S,Krishnamurthy B,Walsh TH

    更新日期:2004-09-01 00:00:00

  • Local anesthesia use for laparoscopic cholecystectomy.

    abstract::This study aimed to investigate the effects and timing of local anesthesia during laparoscopic surgery in terms of postoperative pain, nausea, and the need for opioids and antiemetics. This prospective study was carried out on 142 patients who underwent laparoscopic cholecystectomy. Peroperative local anesthesia was n...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7350-3

    authors: Inan A,Sen M,Dener C

    更新日期:2004-08-01 00:00:00

  • Prognostic impact of Fas ligand on hepatocellular carcinoma after hepatectomy.

    abstract::The expression of Fas ligand on tumor cells may counterattack the host's immunity and worsen the prognosis. Knowledge of the prognostic impact of Fas ligand on patients with hepatocellular carcinoma (HCC) after hepatectomy is still limited. Fas ligand expression in HCCs was examined in 59 patients who underwent hepate...

    journal_title:World journal of surgery

    pub_type: 杂志文章

    doi:10.1007/s00268-004-7254-2

    authors: Lee WC,Yu MC,Chen MF

    更新日期:2004-08-01 00:00:00

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